Trial information
A Study of the Effect of CPAP in Patients With Diastolic Heart Failure and Sleep-Related Breathing Disorder.
Status: Recruiting
Protocol number: RD000000388
Company division: Diagnostic
Official Scientific Title: Evaluation of the efficacy of treatment with CPAP (continuous postive airway pressure) in patients with diastolic HF (HF with systolic function preserved) and sleep-related breathing disorder.
Brief summary: This study will evaluate the efficacy of treatment with continuous postive airway pressure (as assessed by measurement of NT-proBNP and a number of echocardiographic variables) in patients with diastolic heart failure and sleep-related breathing disorders. The effect of reversing signs of diastolic dysfunction on long term prognosis in these patients will be evaluated.
Condition: Sleep Apnea Syndromes
Intervention type: Diagnostic Test
Intervention name: ELECSYS®proBNP
Inclusion criteria:
- >=1 documented episode of heart failure;
- clinically stable;
- no change of treatment in the month prior to inclusion in the study;
- presence of >=2 abnormal diastolic function indices.
Exclusion criteria:
- base rhythm different from normal sinus rhythm;
- severe lung disease;
- significant primary heart disease;
- unstable angina pectoris, acute myocardial infarction or heart surgery in 3 months prior to inclusion in study.
Gender: Males or Females
Age limits: Min: 40 Years Max: 80 Years
Accepts healthy volunteers: No
Anticipated start date: February, 2006
Trial registration date: 12/06/2006
Date last updated: 9/29/2008
Link to trial result
This trial is being conducted at the following locations:
Portugal
Spain
- Madrid
- Santander
- Santiago
- Valladolid
- Vitoria
